Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation
نویسندگان
چکیده
منابع مشابه
Cooperative transcriptional repression by BCL6 and BACH2 in germinal center B-cell differentiation.
The transcriptional repressors BCL6 and BACH2 are crucial regulators of germinal center (GC) B-cell fate, and are known to interact and repress transcription of PRDM1, a key driver of plasma cell differentiation. How these factors cooperate is not fully understood. Herein, we show that GC formation is only minimally impaired in Bcl6(+/-) or Bach2(+/-) mice, although double heterozygous Bcl6(+/-...
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ژورنال
عنوان ژورنال: Blood
سال: 2014
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2013-07-518605